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- ****************************************
- * Tyrosine kinase phosphorylation site *
- ****************************************
-
- Substrates of tyrosine protein kinases are generally characterized by a lysine
- or an arginine seven residues to the N-terminal side of the phosphorylated
- tyrosine. An acidic residue (Asp or Glu) is often found at either three or
- four residues to the N-terminal side of the tyrosine [1,2,3]. There are a
- number of exceptions to this rule such as the tyrosine phosphorylation sites
- of enolase and lipocortin II.
-
- -Consensus pattern: [RK]-x(2)-[DE]-x(3)-Y
- or [RK]-x(3)-[DE]-x(2)-Y
- [Y is the phosphorylation site]
- -Last update: June 1988 / First entry.
-
- [ 1] Patschinsky T., Hunter T., Esch F.S., Cooper J.A., Sefton B.M.
- Proc. Natl. Acad. Sci. U.S.A. 79:973-977(1982).
- [ 2] Hunter T.
- J. Biol. Chem. 257:4843-4848(1982).
- [ 3] Cooper J.A., Esch F.S., Taylor S.S., Hunter T.
- J. Biol. Chem. 259:7835-7841(1984).
-